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Human Gamma-secretase subunit APH-1A (aa 1-265)
PSF Swiss Prot#
Q96BI3
PSF Protein names
Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor)
PSF Gene names
APH1A (PSF) (CGI-78) (UNQ579/PRO1141)
Organism
Homo sapiens (Human)
PSF Entry name
APH1A_HUMAN
PSF Codon optimized cDNA(gene) Clone
PSF Cat #
RPM0072
Tag
PSF contains A 6x histidine tag
PSF Formulation
Liquid
PSF Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
PSF Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant PSF Protein
PSF Cat #
PM0072
PSF Source
recombinant
PSF Applications
Western Blot, SDS-Page or may be used for other applications determined by user
PSF Purity
>90%, as determined by SDS-PAGE under reducing conditions
PSF Activity
N/A
Tag
PSF Contains A 6x histidine tag
PSF Formulation
Liquid
PSF Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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PSF family
APH-1 family
PSF Subcellular locations
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus > Golgi stack membrane; Multi-pass membrane protein.
PSF FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
PSF Sequence
DDBJ EMBL GenBank
PSF 3D structure
ModBase
PSF interaction
STRING
PSF Proteomic
PRIDE
PSF Genome annotation
Ensembl GeneID KEGG UCSC
PSF Organism specific
CTD MGI
PSF Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
PSF Gene expression
Bgee ArrayExpress Genevestigator
PSF Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY