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Human Gamma-secretase subunit PEN-2 (aa 1-101)

PEN2 Swiss Prot#

Q9NZ42

PEN2 Protein names

Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2)

PEN2 Gene names

PSENEN (PEN2) (MDS033)

Organism

Homo sapiens (Human)

PEN2 Entry name

PEN2_HUMAN

PEN2 Codon optimized cDNA(gene) Clone

PEN2 Cat #

RPM0071

Tag

PEN2 contains A 6x histidine tag

PEN2 Formulation

Liquid

PEN2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PEN2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PEN2 Protein

PEN2 Cat #

PM0071

PEN2 Source

recombinant

PEN2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PEN2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PEN2 Activity

N/A

Tag

PEN2 Contains A 6x histidine tag

PEN2 Formulation

Liquid

PEN2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PEN2 family

PEN-2 family

PEN2 Subcellular locations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus > Golgi stack membrane; Multi-pass membrane protein.

PEN2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.

PEN2 Sequence

DDBJ

EMBL

GenBank

PEN2 3D structure

ModBase

PEN2 interaction

STRING

PEN2 Proteomic

PRIDE

PEN2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PEN2 Organism specific

CTD

MGI

PEN2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PEN2 Gene expression

Bgee

ArrayExpress

Genevestigator

PEN2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY