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Human COP9 signalosome complex subunit 2 (aa 1-443)

CSN2 Swiss Prot#

P61201

CSN2 Protein names

COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TRIP-15) (Alien homolog)

CSN2 Gene names

COPS2 (CSN2) (TRIP15)

Organism

Homo sapiens (Human)

CSN2 Entry name

CSN2_HUMAN

CSN2 Codon optimized cDNA(gene) Clone

CSN2 Cat #

RPM0059

Tag

CSN2 contains A 6x histidine tag

CSN2 Formulation

Liquid

CSN2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CSN2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CSN2 Protein

CSN2 Cat #

PM0059

CSN2 Source

recombinant

CSN2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CSN2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CSN2 Activity

N/A

Tag

CSN2 Contains A 6x histidine tag

CSN2 Formulation

Liquid

CSN2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CSN2 family

CSN2 family

CSN2 Subcellular locations

Cytoplasm. Nucleus.

CSN2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

CSN2 Sequence

DDBJ

EMBL

GenBank

CSN2 3D structure

ModBase

CSN2 interaction

STRING

CSN2 Proteomic

PRIDE

CSN2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CSN2 Organism specific

CTD

MGI

CSN2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CSN2 Gene expression

Bgee

ArrayExpress

Genevestigator

CSN2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY