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Mouse Pituitary homeobox 3 (aa 1-302)

Pitx3 Swiss Prot#

O35160

Pitx3 Protein names

Pituitary homeobox 3 (Paired-like homeodomain transcription factor 3) (Homeobox protein PITX3)

Pitx3 Gene names

Pitx3

Organism

Mouse

Pitx3 Entry name

PITX3_MOUSE

Pitx3 Codon optimized cDNA(gene) Clone

Pitx3 Cat #

RPX0113

Tag

Pitx3 contains A 6x histidine tag

Pitx3 Formulation

Liquid

Pitx3 Storage

Ship at Room temperature.. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Pitx3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Pitx3 Protein

t Pitx3 Cat #

PX0113

Pitx3 Source

t protein

t Pitx3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

t Pitx3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

t Pitx3 Activity

N/A

t Tag

t Pitx3 Contains A 6x histidine tag

t Pitx3 Formulation

Liquid

t Pitx3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Pitx3 family

Paired homeobox family, Bicoid subfamily

Pitx3 Subcellular locations

Nucleus.

Pitx3 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle.

Pitx3 Sequence

DDBJ

EMBL

GenBank

Pitx3 3D structure

ModBase

Pitx3 interaction

STRING

Pitx3 Proteomic

PRIDE

Pitx3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Pitx3 Organism specific

CTD

MGI

Pitx3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Pitx3 Gene expression

Bgee

ArrayExpress

Genevestigator

Pitx3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY