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Human Kallikrein-6 (aa 17-244)

PRSS18 Swiss Prot#

Q92876

PRSS18 Protein names

Kallikrein-6 (EC 3.4.21.-) (Protease M) (Neurosin) (Zyme) (SP59) (Serine protease 9) (Serine protease 18)

PRSS18 Gene names

KLK6 (PRSS18) (PRSS9)

Organism

Human

PRSS18 Entry name

KLK6_HUMAN

PRSS18 Codon optimized cDNA(gene) Clone

PRSS18 Cat #

RPX0083

Tag

PRSS18 contains A 6x histidine tag

PRSS18 Formulation

Liquid

PRSS18 Storage

Ship at Room temperature.. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PRSS18 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PRSS18 Protein

t PRSS18 Cat #

PX0083

PRSS18 Source

t protein

t PRSS18 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

t PRSS18 Purity

>90%, as determined by SDS-PAGE under reducing conditions

t PRSS18 Activity

N/A

t Tag

t PRSS18 Contains A 6x histidine tag

t PRSS18 Formulation

Liquid

t PRSS18 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PRSS18 family

Peptidase S1 family, Kallikrein subfamily

PRSS18 Subcellular locations

Secreted. Nucleus > nucleolus. Cytoplasm. Mitochondrion. Microsome.

PRSS18 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

PRSS18 Sequence

DDBJ

EMBL

GenBank

PRSS18 3D structure

ModBase

PRSS18 interaction

STRING

PRSS18 Proteomic

PRIDE

PRSS18 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PRSS18 Organism specific

CTD

MGI

PRSS18 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PRSS18 Gene expression

Bgee

ArrayExpress

Genevestigator

PRSS18 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY