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Human Norrin (aa 25-133)

EVR2 Swiss Prot#

Q00604

EVR2 Protein names

Norrin (Norrie disease protein) (X-linked exudative vitreoretinopathy 2 protein)

EVR2 Gene names

NDP (EVR2)

Organism

Human

EVR2 Entry name

NDP_HUMAN

EVR2 Codon optimized cDNA(gene) Clone

EVR2 Cat #

RPX0051

Tag

EVR2 contains A 6x histidine tag

EVR2 Formulation

Liquid

EVR2 Storage

Ship at Room temperature.. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

EVR2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant EVR2 Protein

t EVR2 Cat #

PX0051

EVR2 Source

t protein

t EVR2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

t EVR2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

t EVR2 Activity

N/A

t Tag

t EVR2 Contains A 6x histidine tag

t EVR2 Formulation

Liquid

t EVR2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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EVR2 family

-

EVR2 Subcellular locations

Secreted.

EVR2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

EVR2 Sequence

DDBJ

EMBL

GenBank

EVR2 3D structure

ModBase

EVR2 interaction

STRING

EVR2 Proteomic

PRIDE

EVR2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

EVR2 Organism specific

CTD

MGI

EVR2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

EVR2 Gene expression

Bgee

ArrayExpress

Genevestigator

EVR2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY