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Human Leucine-rich glioma-inactivated protein 1 (aa 35- 557)

EPT Swiss Prot#

O95970

EPT Protein names

Leucine-rich glioma-inactivated protein 1 (Epitempin-1)

EPT Gene names

LGI1 (EPT) (UNQ775/PRO1569)

Organism

Human

EPT Entry name

LGI1_HUMAN

EPT Codon optimized cDNA(gene) Clone

EPT Cat #

RPX0020

Tag

EPT contains A 6x histidine tag

EPT Formulation

Liquid

EPT Storage

Ship at Room temperature.. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

EPT Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant EPT Protein

t EPT Cat #

PX0020

EPT Source

t protein

t EPT Applications

Western Blot, SDS-Page or may be used for other applications determined by user

t EPT Purity

>90%, as determined by SDS-PAGE under reducing conditions

t EPT Activity

N/A

t Tag

t EPT Contains A 6x histidine tag

t EPT Formulation

Liquid

t EPT Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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EPT family

-

EPT Subcellular locations

Secreted. Cell junction > synapse.

EPT FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.

EPT Sequence

DDBJ

EMBL

GenBank

EPT 3D structure

ModBase

EPT interaction

STRING

EPT Proteomic

PRIDE

EPT Genome annotation

Ensembl

GeneID

KEGG

UCSC

EPT Organism specific

CTD

MGI

EPT Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

EPT Gene expression

Bgee

ArrayExpress

Genevestigator

EPT Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY