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Human Dual specificity tyrosine-phosphorylation-regulated 2 (aa 1-601 )
DYRK2 Swiss Prot#
Q92630
DYRK2 Protein names
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)
DYRK2 Gene names
DYRK2
Organism
Human
DYRK2 Entry name
DYRK2_HUMAN
DYRK2 Codon optimized cDNA(gene) Clone
DYRK2 Cat #
RPC0477
Tag
DYRK2 contains A 6x histidine tag
DYRK2 Formulation
Liquid
DYRK2 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
DYRK2 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant DYRK2 Protein
DYRK2 Cat #
PC0477
DYRK2 Source
recombinant
DYRK2 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
DYRK2 Purity
>90%, as determined by SDS-PAGE under reducing conditions
DYRK2 Activity
N/A
Tag
DYRK2 Contains A 6x histidine tag
DYRK2 Formulation
Liquid
DYRK2 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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DYRK2 family
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily
DYRK2 Subcellular locations
Cytoplasm. Nucleus.
DYRK2 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
DYRK2 Sequence
DDBJ EMBL GenBank
DYRK2 3D structure
ModBase
DYRK2 interaction
STRING
DYRK2 Proteomic
PRIDE
DYRK2 Genome annotation
Ensembl GeneID KEGG UCSC
DYRK2 Organism specific
CTD MGI
DYRK2 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
DYRK2 Gene expression
Bgee ArrayExpress Genevestigator
DYRK2 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY