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| Human Dual specificity tyrosine-phosphorylation-regulated 2 (aa 1-601 ) |
| DYRK2 Swiss Prot# | | Q92630 |
| DYRK2 Protein names | | Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) |
| DYRK2 Gene names | | DYRK2 |
| Organism | | Human |
| DYRK2 Entry name | | DYRK2_HUMAN |
| DYRK2 Codon optimized cDNA(gene) Clone |
| DYRK2 Cat # | | RPC0477 |
| Tag | | DYRK2 contains A 6x histidine tag |
| DYRK2 Formulation | | Liquid |
| DYRK2 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| DYRK2 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant DYRK2 Protein |
| DYRK2 Cat # | | PC0477 |
| DYRK2 Source | | recombinant |
| DYRK2 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| DYRK2 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| DYRK2 Activity | | N/A |
| Tag | | DYRK2 Contains A 6x histidine tag |
| DYRK2 Formulation | | Liquid |
| DYRK2 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant DYRK2 Products | | For pricing and availability Click Here >>> |
| DYRK2 family | | Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily |
| DYRK2 Subcellular locations | | Cytoplasm. Nucleus. |
| DYRK2 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates. |
| DYRK2 Sequence | | DDBJ | EMBL | GenBank |
| DYRK2 3D structure | | ModBase |
| DYRK2 interaction | | STRING |
| DYRK2 Proteomic | | PRIDE |
| DYRK2 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| DYRK2 Organism specific | | CTD | MGI |
| DYRK2 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| DYRK2 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| DYRK2 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |