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Human 5'-AMP-activated protein kinase catalytic subunit alpha-2 (aa 1-552)

AMPK Swiss Prot#

P54646

AMPK Protein names

5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK alpha-2 chain) (EC 2.7.11.1)

AMPK Gene names

PRKAA2 (AMPK) (AMPK2)

Organism

Human

AMPK Entry name

AAPK2_HUMAN

AMPK Codon optimized cDNA(gene) Clone

AMPK Cat #

RPC0432

Tag

AMPK contains A 6x histidine tag

AMPK Formulation

Liquid

AMPK Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

AMPK Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant AMPK Protein

AMPK Cat #

PC0432

AMPK Source

recombinant

AMPK Applications

Western Blot, SDS-Page or may be used for other applications determined by user

AMPK Purity

>90%, as determined by SDS-PAGE under reducing conditions

AMPK Activity

N/A

Tag

AMPK Contains A 6x histidine tag

AMPK Formulation

Liquid

AMPK Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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AMPK family

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily

AMPK Subcellular locations

-

AMPK FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.

AMPK Sequence

DDBJ

EMBL

GenBank

AMPK 3D structure

ModBase

AMPK interaction

STRING

AMPK Proteomic

PRIDE

AMPK Genome annotation

Ensembl

GeneID

KEGG

UCSC

AMPK Organism specific

CTD

MGI

AMPK Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

AMPK Gene expression

Bgee

ArrayExpress

Genevestigator

AMPK Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY