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Human Serine threonine-protein kinase PAK 1 (aa 1-545)

PAK1 Swiss Prot#

Q13153

PAK1 Protein names

Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (p65-PAK) (Alpha-PAK)

PAK1 Gene names

PAK1

Organism

Human

PAK1 Entry name

PAK1_HUMAN

PAK1 Codon optimized cDNA(gene) Clone

PAK1 Cat #

RPC0423

Tag

PAK1 contains A 6x histidine tag

PAK1 Formulation

Liquid

PAK1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PAK1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PAK1 Protein

PAK1 Cat #

PC0423

PAK1 Source

recombinant

PAK1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PAK1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PAK1 Activity

N/A

Tag

PAK1 Contains A 6x histidine tag

PAK1 Formulation

Liquid

PAK1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PAK1 family

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily

PAK1 Subcellular locations

Cytoplasm. Cell junction > focal adhesion.

PAK1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

PAK1 Sequence

DDBJ

EMBL

GenBank

PAK1 3D structure

ModBase

PAK1 interaction

STRING

PAK1 Proteomic

PRIDE

PAK1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PAK1 Organism specific

CTD

MGI

PAK1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PAK1 Gene expression

Bgee

ArrayExpress

Genevestigator

PAK1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY