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Human Proto-oncogene tyrosine-protein kinase Src (aa 2-536)

SRC1 Swiss Prot#

P12931

SRC1 Protein names

Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (pp60c-src) (p60-Src) (c-Src)

SRC1 Gene names

SRC (SRC1)

Organism

Human

SRC1 Entry name

SRC_HUMAN

SRC1 Codon optimized cDNA(gene) Clone

SRC1 Cat #

RPC0410

Tag

SRC1 contains A 6x histidine tag

SRC1 Formulation

Liquid

SRC1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

SRC1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant SRC1 Protein

SRC1 Cat #

PC0410

SRC1 Source

recombinant

SRC1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

SRC1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

SRC1 Activity

N/A

Tag

SRC1 Contains A 6x histidine tag

SRC1 Formulation

Liquid

SRC1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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SRC1 family

Protein kinase superfamily, Tyr protein kinase family, SRC subfamily

SRC1 Subcellular locations

Cell membrane. Mitochondrion inner membrane.

SRC1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling.

SRC1 Sequence

DDBJ

EMBL

GenBank

SRC1 3D structure

ModBase

SRC1 interaction

STRING

SRC1 Proteomic

PRIDE

SRC1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

SRC1 Organism specific

CTD

MGI

SRC1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SRC1 Gene expression

Bgee

ArrayExpress

Genevestigator

SRC1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY