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Human Pyruvate kinase isozymes M1 M2 (aa 2-531)

PK2 Swiss Prot#

P14618

PK2 Protein names

Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40) (Pyruvate kinase muscle isozyme) (Pyruvate kinase 2/3) (Cytosolic thyroid hormone-binding protein) (CTHBP) (THBP1)

PK2 Gene names

PKM2 (PK2) (PK3) (PKM)

Organism

Human

PK2 Entry name

KPYM_HUMAN

PK2 Codon optimized cDNA(gene) Clone

PK2 Cat #

RPC0407

Tag

PK2 contains A 6x histidine tag

PK2 Formulation

Liquid

PK2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PK2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PK2 Protein

PK2 Cat #

PC0407

PK2 Source

recombinant

PK2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PK2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PK2 Activity

N/A

Tag

PK2 Contains A 6x histidine tag

PK2 Formulation

Liquid

PK2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PK2 family

Pyruvate kinase family

PK2 Subcellular locations

Cytoplasm. Nucleus.

PK2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

PK2 Sequence

DDBJ

EMBL

GenBank

PK2 3D structure

ModBase

PK2 interaction

STRING

PK2 Proteomic

PRIDE

PK2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PK2 Organism specific

CTD

MGI

PK2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PK2 Gene expression

Bgee

ArrayExpress

Genevestigator

PK2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY