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Human S-phase kinase-associated protein 2 (aa 1-424)

FBXL1 Swiss Prot#

Q13309

FBXL1 Protein names

S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1)

FBXL1 Gene names

SKP2 (FBXL1)

Organism

Human

FBXL1 Entry name

SKP2_HUMAN

FBXL1 Codon optimized cDNA(gene) Clone

FBXL1 Cat #

RPC0288

Tag

FBXL1 contains A 6x histidine tag

FBXL1 Formulation

Liquid

FBXL1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

FBXL1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant FBXL1 Protein

FBXL1 Cat #

PC0288

FBXL1 Source

recombinant

FBXL1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

FBXL1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

FBXL1 Activity

N/A

Tag

FBXL1 Contains A 6x histidine tag

FBXL1 Formulation

Liquid

FBXL1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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FBXL1 family

-

FBXL1 Subcellular locations

-

FBXL1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1A, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2.

FBXL1 Sequence

DDBJ

EMBL

GenBank

FBXL1 3D structure

ModBase

FBXL1 interaction

STRING

FBXL1 Proteomic

PRIDE

FBXL1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

FBXL1 Organism specific

CTD

MGI

FBXL1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

FBXL1 Gene expression

Bgee

ArrayExpress

Genevestigator

FBXL1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY