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Human Proto-oncogene serine threonine-protein kinase Pim-1 (aa 1-404)

PIM1 Swiss Prot#

P11309

PIM1 Protein names

Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1)

PIM1 Gene names

PIM1

Organism

Human

PIM1 Entry name

PIM1_HUMAN

PIM1 Codon optimized cDNA(gene) Clone

PIM1 Cat #

RPC0251

Tag

PIM1 contains A 6x histidine tag

PIM1 Formulation

Liquid

PIM1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PIM1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PIM1 Protein

PIM1 Cat #

PC0251

PIM1 Source

recombinant

PIM1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PIM1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PIM1 Activity

N/A

Tag

PIM1 Contains A 6x histidine tag

PIM1 Formulation

Liquid

PIM1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PIM1 family

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, PIM subfamily

PIM1 Subcellular locations

Cytoplasm. Nucleus. Cell membrane.

PIM1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Isoform 2 promotes the G1/S transition of the cell cycle via up-regulation of CDK2 activity and phosphorylation of CDKN1B, resulting in enhanced nuclear export and proteasome-dependent degradation of CDKN1B. Isoform 2 also represses CDKN1B transcription by phosphorylating and inactivating the transcription factor FOXO3. Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provides a selective advantage in tumorigenesis.

PIM1 Sequence

DDBJ

EMBL

GenBank

PIM1 3D structure

ModBase

PIM1 interaction

STRING

PIM1 Proteomic

PRIDE

PIM1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PIM1 Organism specific

CTD

MGI

PIM1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PIM1 Gene expression

Bgee

ArrayExpress

Genevestigator

PIM1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY