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Human Serine threonine-protein kinase 6 (aa 1-403)

AIK Swiss Prot#

O14965

AIK Protein names

Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora kinase A) (Aurora-A) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase)

AIK Gene names

AURKA (AIK) (ARK1) (AURA) (BTAK) (STK15) (STK6)

Organism

Human

AIK Entry name

STK6_HUMAN

AIK Codon optimized cDNA(gene) Clone

AIK Cat #

RPC0249

Tag

AIK contains A 6x histidine tag

AIK Formulation

Liquid

AIK Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

AIK Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant AIK Protein

AIK Cat #

PC0249

AIK Source

recombinant

AIK Applications

Western Blot, SDS-Page or may be used for other applications determined by user

AIK Purity

>90%, as determined by SDS-PAGE under reducing conditions

AIK Activity

N/A

Tag

AIK Contains A 6x histidine tag

AIK Formulation

Liquid

AIK Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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AIK family

Protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily

AIK Subcellular locations

Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle pole.

AIK FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Contributes to the regulation of cell cycle progression. Required for normal mitosis. Associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. Phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Regulates KIF2A tubulin depolymerase activity (By similarity). Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization.

AIK Sequence

DDBJ

EMBL

GenBank

AIK 3D structure

ModBase

AIK interaction

STRING

AIK Proteomic

PRIDE

AIK Genome annotation

Ensembl

GeneID

KEGG

UCSC

AIK Organism specific

CTD

MGI

AIK Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

AIK Gene expression

Bgee

ArrayExpress

Genevestigator

AIK Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY