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Human Serine threonine-protein kinase ORF66 (aa 1-393)

66 Swiss Prot#

P09251

66 Protein names

Serine/threonine-protein kinase ORF66 (EC 2.7.11.1)

66 Gene names

66

Organism

Human

66 Entry name

US03_VZVD

66 Codon optimized cDNA(gene) Clone

66 Cat #

RPC0230

Tag

66 contains A 6x histidine tag

66 Formulation

Liquid

66 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

66 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant 66 Protein

66 Cat #

PC0230

66 Source

recombinant

66 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

66 Purity

>90%, as determined by SDS-PAGE under reducing conditions

66 Activity

N/A

Tag

66 Contains A 6x histidine tag

66 Formulation

Liquid

66 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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66 family

Protein kinase superfamily, Ser/Thr protein kinase family

66 Subcellular locations

Host cytoplasm. Host nucleus.

66 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and inhibition of apoptosis. Phosphorylates proteins 24 and 27, two critical regulators of capsid budding from nucleus to endoplasmic reticulum, thereby facilitating virion egress. Modulates and redistributes host components of the nuclear envelope, including LMNA, emerin/EMD and the nuclear matrix protein MATR3. Phosphorylates envelope glycoprotein B (gB), probably to direct it to the cell surface. Promotes virus intracellular spread by restructuring host cell cytoskeleton. Blocks host apoptosis to extend cell survival and allow efficient viral replication. Promotes viral gene expression by phosphorylating host HDAC2 to reduce viral genome silencing (By similarity). Downregulates class I major histocompatibility complex (MHC-I) surface expression. Additionally, phosphorylates IE62 and targets it to the cytoplasm. The nuclear exclusion of IE62 enables the packaging of abundant levels of IE62 into virions.

66 Sequence

DDBJ

EMBL

GenBank

66 3D structure

ModBase

66 interaction

STRING

66 Proteomic

PRIDE

66 Genome annotation

Ensembl

GeneID

KEGG

UCSC

66 Organism specific

CTD

MGI

66 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

66 Gene expression

Bgee

ArrayExpress

Genevestigator

66 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY