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Human p21-activated protein kinase-interacting protein 1 (aa 1-392)

PIP1 Swiss Prot#

Q9NWT1

PIP1 Protein names

p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (PAK/PLC-interacting protein 1) (hPIP1) (WD repeat-containing protein 84)

PIP1 Gene names

PAK1IP1 (PIP1) (WDR84)

Organism

Human

PIP1 Entry name

PK1IP_HUMAN

PIP1 Codon optimized cDNA(gene) Clone

PIP1 Cat #

RPC0229

Tag

PIP1 contains A 6x histidine tag

PIP1 Formulation

Liquid

PIP1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PIP1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PIP1 Protein

PIP1 Cat #

PC0229

PIP1 Source

recombinant

PIP1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PIP1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PIP1 Activity

N/A

Tag

PIP1 Contains A 6x histidine tag

PIP1 Formulation

Liquid

PIP1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PIP1 family

-

PIP1 Subcellular locations

Nucleus > nucleolus.

PIP1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42.

PIP1 Sequence

DDBJ

EMBL

GenBank

PIP1 3D structure

ModBase

PIP1 interaction

STRING

PIP1 Proteomic

PRIDE

PIP1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PIP1 Organism specific

CTD

MGI

PIP1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PIP1 Gene expression

Bgee

ArrayExpress

Genevestigator

PIP1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY