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Human Mitogen-activated protein kinase 12 (aa 1-367)

ERK6 Swiss Prot#

P53778

ERK6 Protein names

Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma)

ERK6 Gene names

MAPK12 (ERK6) (SAPK3)

Organism

Human

ERK6 Entry name

MK12_HUMAN

ERK6 Codon optimized cDNA(gene) Clone

ERK6 Cat #

RPC0194

Tag

ERK6 contains A 6x histidine tag

ERK6 Formulation

Liquid

ERK6 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ERK6 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ERK6 Protein

ERK6 Cat #

PC0194

ERK6 Source

recombinant

ERK6 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ERK6 Purity

>90%, as determined by SDS-PAGE under reducing conditions

ERK6 Activity

N/A

Tag

ERK6 Contains A 6x histidine tag

ERK6 Formulation

Liquid

ERK6 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ERK6 family

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily

ERK6 Subcellular locations

Cytoplasm. Mitochondrion.

ERK6 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.

ERK6 Sequence

DDBJ

EMBL

GenBank

ERK6 3D structure

ModBase

ERK6 interaction

STRING

ERK6 Proteomic

PRIDE

ERK6 Genome annotation

Ensembl

GeneID

KEGG

UCSC

ERK6 Organism specific

CTD

MGI

ERK6 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ERK6 Gene expression

Bgee

ArrayExpress

Genevestigator

ERK6 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY