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Human Tribbles homolog 3 (aa 1-358)

C20orf97 Swiss Prot#

Q96RU7

C20orf97 Protein names

Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappa-B) (SINK)

C20orf97 Gene names

TRIB3 (C20orf97) (NIPK) (SKIP3) (TRB3)

Organism

Human

C20orf97 Entry name

TRIB3_HUMAN

C20orf97 Codon optimized cDNA(gene) Clone

C20orf97 Cat #

RPC0180

Tag

C20orf97 contains A 6x histidine tag

C20orf97 Formulation

Liquid

C20orf97 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

C20orf97 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant C20orf97 Protein

C20orf97 Cat #

PC0180

C20orf97 Source

recombinant

C20orf97 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

C20orf97 Purity

>90%, as determined by SDS-PAGE under reducing conditions

C20orf97 Activity

N/A

Tag

C20orf97 Contains A 6x histidine tag

C20orf97 Formulation

Liquid

C20orf97 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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C20orf97 family

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, Tribbles subfamily

C20orf97 Subcellular locations

Nucleus.

C20orf97 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.

C20orf97 Sequence

DDBJ

EMBL

GenBank

C20orf97 3D structure

ModBase

C20orf97 interaction

STRING

C20orf97 Proteomic

PRIDE

C20orf97 Genome annotation

Ensembl

GeneID

KEGG

UCSC

C20orf97 Organism specific

CTD

MGI

C20orf97 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

C20orf97 Gene expression

Bgee

ArrayExpress

Genevestigator

C20orf97 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY