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Human Cell division protein kinase 7 (aa 1-346)

MO15 Swiss Prot#

P50613

MO15 Protein names

Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK-activating kinase) (CAK) (CAK1) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1)

MO15 Gene names

CDK7 (MO15)

Organism

Human

MO15 Entry name

CDK7_HUMAN

MO15 Codon optimized cDNA(gene) Clone

MO15 Cat #

RPC0165

Tag

MO15 contains A 6x histidine tag

MO15 Formulation

Liquid

MO15 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MO15 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MO15 Protein

MO15 Cat #

PC0165

MO15 Source

recombinant

MO15 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MO15 Purity

>90%, as determined by SDS-PAGE under reducing conditions

MO15 Activity

N/A

Tag

MO15 Contains A 6x histidine tag

MO15 Formulation

Liquid

MO15 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MO15 family

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily

MO15 Subcellular locations

Nucleus.

MO15 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between two subsequent phases in the cell cycle. CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

MO15 Sequence

DDBJ

EMBL

GenBank

MO15 3D structure

ModBase

MO15 interaction

STRING

MO15 Proteomic

PRIDE

MO15 Genome annotation

Ensembl

GeneID

KEGG

UCSC

MO15 Organism specific

CTD

MGI

MO15 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MO15 Gene expression

Bgee

ArrayExpress

Genevestigator

MO15 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY