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Human Serine threonine-protein kinase 12 (aa 1-344)

AIK2 Swiss Prot#

Q96GD4

AIK2 Protein names

Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1)

AIK2 Gene names

AURKB (AIK2) (AIM1) (ARK2) (STK12)

Organism

Human

AIK2 Entry name

AURKB_HUMAN

AIK2 Codon optimized cDNA(gene) Clone

AIK2 Cat #

RPC0161

Tag

AIK2 contains A 6x histidine tag

AIK2 Formulation

Liquid

AIK2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

AIK2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant AIK2 Protein

AIK2 Cat #

PC0161

AIK2 Source

recombinant

AIK2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

AIK2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

AIK2 Activity

N/A

Tag

AIK2 Contains A 6x histidine tag

AIK2 Formulation

Liquid

AIK2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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AIK2 family

Protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily

AIK2 Subcellular locations

Nucleus. Chromosome. Chromosome > centromere. Cytoplasm > cytoskeleton > spindle.

AIK2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1. Interacts with INCENP.

AIK2 Sequence

DDBJ

EMBL

GenBank

AIK2 3D structure

ModBase

AIK2 interaction

STRING

AIK2 Proteomic

PRIDE

AIK2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

AIK2 Organism specific

CTD

MGI

AIK2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

AIK2 Gene expression

Bgee

ArrayExpress

Genevestigator

AIK2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY