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Human Lymphokine-activated killer T-cell-originated kinase (aa 1-322)

TOPK Swiss Prot#

Q96KB5

TOPK Protein names

Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3) (Cancer/testis antigen 84) (CT84)

TOPK Gene names

PBK (TOPK)

Organism

Human

TOPK Entry name

TOPK_HUMAN

TOPK Codon optimized cDNA(gene) Clone

TOPK Cat #

RPC0134

Tag

TOPK contains A 6x histidine tag

TOPK Formulation

Liquid

TOPK Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

TOPK Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant TOPK Protein

TOPK Cat #

PC0134

TOPK Source

recombinant

TOPK Applications

Western Blot, SDS-Page or may be used for other applications determined by user

TOPK Purity

>90%, as determined by SDS-PAGE under reducing conditions

TOPK Activity

N/A

Tag

TOPK Contains A 6x histidine tag

TOPK Formulation

Liquid

TOPK Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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TOPK family

Protein kinase superfamily, Ser/Thr protein kinase family, MAP kinase kinase subfamily

TOPK Subcellular locations

-

TOPK FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.

TOPK Sequence

DDBJ

EMBL

GenBank

TOPK 3D structure

ModBase

TOPK interaction

STRING

TOPK Proteomic

PRIDE

TOPK Genome annotation

Ensembl

GeneID

KEGG

UCSC

TOPK Organism specific

CTD

MGI

TOPK Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TOPK Gene expression

Bgee

ArrayExpress

Genevestigator

TOPK Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY