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| Human Serine threonine-protein kinase Pim-2 (aa 1-311) |
| PIM2 Swiss Prot# | | Q9P1W9 |
| PIM2 Protein names | | Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h) |
| PIM2 Gene names | | PIM2 |
| Organism | | Human |
| PIM2 Entry name | | PIM2_HUMAN |
| PIM2 Codon optimized cDNA(gene) Clone |
| PIM2 Cat # | | RPC0123 |
| Tag | | PIM2 contains A 6x histidine tag |
| PIM2 Formulation | | Liquid |
| PIM2 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| PIM2 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant PIM2 Protein |
| PIM2 Cat # | | PC0123 |
| PIM2 Source | | recombinant |
| PIM2 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| PIM2 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| PIM2 Activity | | N/A |
| Tag | | PIM2 Contains A 6x histidine tag |
| PIM2 Formulation | | Liquid |
| PIM2 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant PIM2 Products | | For pricing and availability Click Here >>> |
| PIM2 family | | Protein kinase superfamily, CAMK Ser/Thr protein kinase family, PIM subfamily |
| PIM2 Subcellular locations | | - |
| PIM2 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappaB kinase/NF-kappaB cascade; this process requires phosphorylation of MAP3K8/COT. Prevents apoptosis induced by growth factor withdrawal via inhibition of caspase-3 activation, and via phosphorylation of pro-apoptotic proteins. Inhibits BAD-induced cell death via phosphorylation of BAD. PIM2-mediated cell survival is glucose-dependent but independent of several AKT regulators such as PI3K, HSP-90 and TOR, indicating that PIM2 and PI3K/AKT/TOR function via distinct pathways. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate (By similarity). |
| PIM2 Sequence | | DDBJ | EMBL | GenBank |
| PIM2 3D structure | | ModBase |
| PIM2 interaction | | STRING |
| PIM2 Proteomic | | PRIDE |
| PIM2 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| PIM2 Organism specific | | CTD | MGI |
| PIM2 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| PIM2 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| PIM2 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |