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Human Serine threonine-protein kinase Pim-2 (aa 1-311)
PIM2 Swiss Prot#
Q9P1W9
PIM2 Protein names
Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h)
PIM2 Gene names
PIM2
Organism
Human
PIM2 Entry name
PIM2_HUMAN
PIM2 Codon optimized cDNA(gene) Clone
PIM2 Cat #
RPC0123
Tag
PIM2 contains A 6x histidine tag
PIM2 Formulation
Liquid
PIM2 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
PIM2 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant PIM2 Protein
PIM2 Cat #
PC0123
PIM2 Source
recombinant
PIM2 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
PIM2 Purity
>90%, as determined by SDS-PAGE under reducing conditions
PIM2 Activity
N/A
Tag
PIM2 Contains A 6x histidine tag
PIM2 Formulation
Liquid
PIM2 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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PIM2 family
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, PIM subfamily
PIM2 Subcellular locations
-
PIM2 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappaB kinase/NF-kappaB cascade; this process requires phosphorylation of MAP3K8/COT. Prevents apoptosis induced by growth factor withdrawal via inhibition of caspase-3 activation, and via phosphorylation of pro-apoptotic proteins. Inhibits BAD-induced cell death via phosphorylation of BAD. PIM2-mediated cell survival is glucose-dependent but independent of several AKT regulators such as PI3K, HSP-90 and TOR, indicating that PIM2 and PI3K/AKT/TOR function via distinct pathways. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate (By similarity).
PIM2 Sequence
DDBJ EMBL GenBank
PIM2 3D structure
ModBase
PIM2 interaction
STRING
PIM2 Proteomic
PRIDE
PIM2 Genome annotation
Ensembl GeneID KEGG UCSC
PIM2 Organism specific
CTD MGI
PIM2 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
PIM2 Gene expression
Bgee ArrayExpress Genevestigator
PIM2 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY