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Human CDK-activating kinase assembly factor MAT1 (aa 1-309)

CAP35 Swiss Prot#

P51948

CAP35 Protein names

CDK-activating kinase assembly factor MAT1 (RING finger protein MAT1) (Menage a trois) (CDK7/cyclin H assembly factor) (p36) (p35) (Cyclin G1-interacting protein) (RING finger protein 66)

CAP35 Gene names

MNAT1 (CAP35) (MAT1) (RNF66)

Organism

Human

CAP35 Entry name

MAT1_HUMAN

CAP35 Codon optimized cDNA(gene) Clone

CAP35 Cat #

RPC0121

Tag

CAP35 contains A 6x histidine tag

CAP35 Formulation

Liquid

CAP35 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CAP35 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CAP35 Protein

CAP35 Cat #

PC0121

CAP35 Source

recombinant

CAP35 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CAP35 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CAP35 Activity

N/A

Tag

CAP35 Contains A 6x histidine tag

CAP35 Formulation

Liquid

CAP35 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CAP35 family

-

CAP35 Subcellular locations

Nucleus.

CAP35 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.

CAP35 Sequence

DDBJ

EMBL

GenBank

CAP35 3D structure

ModBase

CAP35 interaction

STRING

CAP35 Proteomic

PRIDE

CAP35 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CAP35 Organism specific

CTD

MGI

CAP35 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CAP35 Gene expression

Bgee

ArrayExpress

Genevestigator

CAP35 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY