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Human Mps one binder kinase activator-like 1B (aa 2-216)

C2orf6 Swiss Prot#

Q9H8S9

C2orf6 Protein names

Mps one binder kinase activator-like 1B (Mob1 homolog 1B) (Mob1 alpha) (Mob1A) (Protein Mob4B)

C2orf6 Gene names

MOBKL1B (C2orf6) (MOB4B) (MOBK1B)

Organism

Human

C2orf6 Entry name

MOL1B_HUMAN

C2orf6 Codon optimized cDNA(gene) Clone

C2orf6 Cat #

RPC0058

Tag

C2orf6 contains A 6x histidine tag

C2orf6 Formulation

Liquid

C2orf6 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

C2orf6 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant C2orf6 Protein

C2orf6 Cat #

PC0058

C2orf6 Source

recombinant

C2orf6 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

C2orf6 Purity

>90%, as determined by SDS-PAGE under reducing conditions

C2orf6 Activity

N/A

Tag

C2orf6 Contains A 6x histidine tag

C2orf6 Formulation

Liquid

C2orf6 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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C2orf6 family

MOB1/phocein family

C2orf6 Subcellular locations

-

C2orf6 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L.

C2orf6 Sequence

DDBJ

EMBL

GenBank

C2orf6 3D structure

ModBase

C2orf6 interaction

STRING

C2orf6 Proteomic

PRIDE

C2orf6 Genome annotation

Ensembl

GeneID

KEGG

UCSC

C2orf6 Organism specific

CTD

MGI

C2orf6 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

C2orf6 Gene expression

Bgee

ArrayExpress

Genevestigator

C2orf6 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY