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Human Ephrin-A1 (aa 18-182)

EPLG1 Swiss Prot#

P20827

EPLG1 Protein names

Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) (Tumor necrosis factor, alpha-induced protein 4)

EPLG1 Gene names

EFNA1 (EPLG1) (LERK1) (TNFAIP4)

Organism

Human

EPLG1 Entry name

EFNA1_HUMAN

EPLG1 Codon optimized cDNA(gene) Clone

EPLG1 Cat #

RPC0049

Tag

EPLG1 contains A 6x histidine tag

EPLG1 Formulation

Liquid

EPLG1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

EPLG1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant EPLG1 Protein

EPLG1 Cat #

PC0049

EPLG1 Source

recombinant

EPLG1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

EPLG1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

EPLG1 Activity

N/A

Tag

EPLG1 Contains A 6x histidine tag

EPLG1 Formulation

Liquid

EPLG1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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EPLG1 family

Ephrin family

EPLG1 Subcellular locations

Cell membrane; Lipid-anchor > GPI-anchor. Secreted.

EPLG1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cones.

EPLG1 Sequence

DDBJ

EMBL

GenBank

EPLG1 3D structure

ModBase

EPLG1 interaction

STRING

EPLG1 Proteomic

PRIDE

EPLG1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

EPLG1 Organism specific

CTD

MGI

EPLG1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

EPLG1 Gene expression

Bgee

ArrayExpress

Genevestigator

EPLG1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY