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Human Calcium and integrin-binding protein 1 (aa 2-191)

CIB Swiss Prot#

Q99828

CIB Protein names

Calcium and integrin-binding protein 1 (CIB) (Calmyrin) (DNA-PKcs-interacting protein) (Kinase-interacting protein) (KIP) (SNK-interacting protein 2-28) (SIP2-28)

CIB Gene names

CIB1 (CIB) (KIP) (PRKDCIP)

Organism

Human

CIB Entry name

CIB1_HUMAN

CIB Codon optimized cDNA(gene) Clone

CIB Cat #

RPC0035

Tag

CIB contains A 6x histidine tag

CIB Formulation

Liquid

CIB Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CIB Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CIB Protein

CIB Cat #

PC0035

CIB Source

recombinant

CIB Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CIB Purity

>90%, as determined by SDS-PAGE under reducing conditions

CIB Activity

N/A

Tag

CIB Contains A 6x histidine tag

CIB Formulation

Liquid

CIB Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CIB family

-

CIB Subcellular locations

Membrane; Lipid-anchor. Cytoplasm. Nucleus. Cell projection > filopodium. Apical cell membrane.

CIB FUNCTION According to UniProtKB Swiss Prot

FUNCTION: May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling.

CIB Sequence

DDBJ

EMBL

GenBank

CIB 3D structure

ModBase

CIB interaction

STRING

CIB Proteomic

PRIDE

CIB Genome annotation

Ensembl

GeneID

KEGG

UCSC

CIB Organism specific

CTD

MGI

CIB Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CIB Gene expression

Bgee

ArrayExpress

Genevestigator

CIB Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY