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Human Protein phosphatase 1 regulatory inhibitor 16B (aa 1-567)

ANKRD4 Swiss Prot#

Q96T49

ANKRD4 Protein names

Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta-inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain-containing protein 4)

ANKRD4 Gene names

PPP1R16B (ANKRD4) (KIAA0823)

Organism

Human

ANKRD4 Entry name

PP16B_HUMAN

ANKRD4 Codon optimized cDNA(gene) Clone

ANKRD4 Cat #

RPT0362

Tag

ANKRD4 contains A 6x histidine tag

ANKRD4 Formulation

Liquid

ANKRD4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ANKRD4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ANKRD4 Protein

ANKRD4 Cat #

PT0362

ANKRD4 Source

recombinant

ANKRD4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ANKRD4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

ANKRD4 Activity

N/A

Tag

ANKRD4 Contains A 6x histidine tag

ANKRD4 Formulation

Liquid

ANKRD4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ANKRD4 family

-

ANKRD4 Subcellular locations

Cell membrane. Cell membrane; Lipid-anchor. Nucleus.

ANKRD4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.

ANKRD4 Sequence

DDBJ

EMBL

GenBank

ANKRD4 3D structure

ModBase

ANKRD4 interaction

STRING

ANKRD4 Proteomic

PRIDE

ANKRD4 Proteomic

Ensembl

GeneID

KEGG

UCSC

ANKRD4 Organism specific

CTD

MGI

ANKRD4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ANKRD4 Gene expression

Bgee

ArrayExpress

Genevestigator

ANKRD4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY