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Human Eyes absent homolog 2 (aa 1-538)

EAB1 Swiss Prot#

O00167

EAB1 Protein names

Eyes absent homolog 2 (EC 3.1.3.48)

EAB1 Gene names

EYA2 (EAB1)

Organism

Human

EAB1 Entry name

EYA2_HUMAN

EAB1 Codon optimized cDNA(gene) Clone

EAB1 Cat #

RPT0346

Tag

EAB1 contains A 6x histidine tag

EAB1 Formulation

Liquid

EAB1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

EAB1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant EAB1 Protein

EAB1 Cat #

PT0346

EAB1 Source

recombinant

EAB1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

EAB1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

EAB1 Activity

N/A

Tag

EAB1 Contains A 6x histidine tag

EAB1 Formulation

Liquid

EAB1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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EAB1 family

HAD-like hydrolase superfamily, EYA family

EAB1 Subcellular locations

Cytoplasm. Nucleus.

EAB1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity.

EAB1 Sequence

DDBJ

EMBL

GenBank

EAB1 3D structure

ModBase

EAB1 interaction

STRING

EAB1 Proteomic

PRIDE

EAB1 Proteomic

Ensembl

GeneID

KEGG

UCSC

EAB1 Organism specific

CTD

MGI

EAB1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

EAB1 Gene expression

Bgee

ArrayExpress

Genevestigator

EAB1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY