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Human Ribosomal protein S6 kinase beta-1 (aa 1-525)

STK14A Swiss Prot#

P23443

STK14A Protein names

Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K1) (S6K) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha)

STK14A Gene names

RPS6KB1 (STK14A)

Organism

Human

STK14A Entry name

KS6B1_HUMAN

STK14A Codon optimized cDNA(gene) Clone

STK14A Cat #

RPT0342

Tag

STK14A contains A 6x histidine tag

STK14A Formulation

Liquid

STK14A Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

STK14A Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant STK14A Protein

STK14A Cat #

PT0342

STK14A Source

recombinant

STK14A Applications

Western Blot, SDS-Page or may be used for other applications determined by user

STK14A Purity

>90%, as determined by SDS-PAGE under reducing conditions

STK14A Activity

N/A

Tag

STK14A Contains A 6x histidine tag

STK14A Formulation

Liquid

STK14A Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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STK14A family

Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily

STK14A Subcellular locations

Cell junction > synapse > synaptosome. Mitochondrion outer membrane. Nucleus. Cytoplasm. Cytoplasm.

STK14A FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Acts to integrate nutrient and growth factor signals in regulation of protein synthesis, cell proliferation, cell growth, cell cycle progression and cell survival. Downstream effector of the mTOR signaling pathway. Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. During translation initiation, the inactive form associatess with the eIF-3 complex under conditions of nutrient depletion. Mitogenic stimulation leads to phosphorylation and dissociation from the eIF-3 complex and the free activated form can phosphorylate other translational targets including EIF4B. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation. Phosphorylates RICTOR leading to regulation of mammalian target of rapamycin complex 2 (mTORC2) signaling; probably phosphorylates RICTOR at 'Thr-1135'. Phosphorylates IRS1 at multiple serine residues coupled with insulin resistance; probably phosphorylates IRS1 at 'Ser-270'. Required for TNF-alpha induced IRS-1 degradation. Phosphorylates EEF2K in response to IGF1 and inhibits EEF2K activity. Phosphorylates BAD at 'Ser-99' in response to IGF1 leading to BAD inactivation and inhibition of BAD-induced apoptosis. Phosphorylates mitochondrial RMP leading to dissociation of a RMP:PPP1CC complex; probably phosphorylates RMP at 'Ser-99'. The free mitochondrial PPP1CC can dephosphorylate RPS6KB1 at Thr-412 which is proposed to be a negative feed back mechanism for the RPS6KB1 antiapoptotic function. Phosphorylates GSK3B at 'Ser-9' under conditions leading to loss of the TSC1-TSC2 complex. Phosphorylates POLDIP3.

STK14A Sequence

DDBJ

EMBL

GenBank

STK14A 3D structure

ModBase

STK14A interaction

STRING

STK14A Proteomic

PRIDE

STK14A Proteomic

Ensembl

GeneID

KEGG

UCSC

STK14A Organism specific

CTD

MGI

STK14A Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

STK14A Gene expression

Bgee

ArrayExpress

Genevestigator

STK14A Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY