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Human Bifunctional polynucleotide phosphatase kinase (aa 1-521)

PNKP Swiss Prot#

Q96T60

PNKP Protein names

Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase-3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase) Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]

PNKP Gene names

PNKP

Organism

Human

PNKP Entry name

PNKP_HUMAN

PNKP Codon optimized cDNA(gene) Clone

PNKP Cat #

RPT0337

Tag

PNKP contains A 6x histidine tag

PNKP Formulation

Liquid

PNKP Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PNKP Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PNKP Protein

PNKP Cat #

PT0337

PNKP Source

recombinant

PNKP Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PNKP Purity

>90%, as determined by SDS-PAGE under reducing conditions

PNKP Activity

N/A

Tag

PNKP Contains A 6x histidine tag

PNKP Formulation

Liquid

PNKP Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PNKP family

DNA 3' phosphatase family

PNKP Subcellular locations

Nucleus.

PNKP FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. Plays an important function in DNA repair following ionizing radiation or oxidative damage.

PNKP Sequence

DDBJ

EMBL

GenBank

PNKP 3D structure

ModBase

PNKP interaction

STRING

PNKP Proteomic

PRIDE

PNKP Proteomic

Ensembl

GeneID

KEGG

UCSC

PNKP Organism specific

CTD

MGI

PNKP Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PNKP Gene expression

Bgee

ArrayExpress

Genevestigator

PNKP Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY