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Human DNA-(apurinic or apyrimidinic site) lyase 2 (aa 1-518)

APE2 Swiss Prot#

Q9UBZ4

APE2 Protein names

DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2)

APE2 Gene names

APEX2 (APE2) (APEXL2) (XTH2)

Organism

Human

APE2 Entry name

APEX2_HUMAN

APE2 Codon optimized cDNA(gene) Clone

APE2 Cat #

RPT0333

Tag

APE2 contains A 6x histidine tag

APE2 Formulation

Liquid

APE2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

APE2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant APE2 Protein

APE2 Cat #

PT0333

APE2 Source

recombinant

APE2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

APE2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

APE2 Activity

N/A

Tag

APE2 Contains A 6x histidine tag

APE2 Formulation

Liquid

APE2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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APE2 family

DNA repair enzymes AP/ExoA family

APE2 Subcellular locations

Nucleus. Cytoplasm. Mitochondrion.

APE2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.

APE2 Sequence

DDBJ

EMBL

GenBank

APE2 3D structure

ModBase

APE2 interaction

STRING

APE2 Proteomic

PRIDE

APE2 Proteomic

Ensembl

GeneID

KEGG

UCSC

APE2 Organism specific

CTD

MGI

APE2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

APE2 Gene expression

Bgee

ArrayExpress

Genevestigator

APE2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY