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Human Dual specificity protein phosphatase CDC14B (aa 1-498)

CDC14B Swiss Prot#

O60729

CDC14B Protein names

Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B)

CDC14B Gene names

CDC14B

Organism

Human

CDC14B Entry name

CC14B_HUMAN

CDC14B Codon optimized cDNA(gene) Clone

CDC14B Cat #

RPT0319

Tag

CDC14B contains A 6x histidine tag

CDC14B Formulation

Liquid

CDC14B Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CDC14B Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CDC14B Protein

CDC14B Cat #

PT0319

CDC14B Source

recombinant

CDC14B Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CDC14B Purity

>90%, as determined by SDS-PAGE under reducing conditions

CDC14B Activity

N/A

Tag

CDC14B Contains A 6x histidine tag

CDC14B Formulation

Liquid

CDC14B Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CDC14B family

Protein-tyrosine phosphatase family, Non-receptor class CDC14 subfamily

CDC14B Subcellular locations

Nucleus > nucleolus. Nucleus > nucleoplasm.

CDC14B FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.

CDC14B Sequence

DDBJ

EMBL

GenBank

CDC14B 3D structure

ModBase

CDC14B interaction

STRING

CDC14B Proteomic

PRIDE

CDC14B Proteomic

Ensembl

GeneID

KEGG

UCSC

CDC14B Organism specific

CTD

MGI

CDC14B Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CDC14B Gene expression

Bgee

ArrayExpress

Genevestigator

CDC14B Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY