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Human Sialic acid-binding Ig-like lectin 7 (aa 19-467

AIRM1 Swiss Prot#

Q9Y286

AIRM1 Protein names

Sialic acid-binding Ig-like lectin 7 (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328) (CD antigen CD328)

AIRM1 Gene names

SIGLEC7 (AIRM1)

Organism

Human

AIRM1 Entry name

SIGL7_HUMAN

AIRM1 Codon optimized cDNA(gene) Clone

AIRM1 Cat #

RPT0284

Tag

AIRM1 contains A 6x histidine tag

AIRM1 Formulation

Liquid

AIRM1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

AIRM1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant AIRM1 Protein

AIRM1 Cat #

PT0284

AIRM1 Source

recombinant

AIRM1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

AIRM1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

AIRM1 Activity

N/A

Tag

AIRM1 Contains A 6x histidine tag

AIRM1 Formulation

Liquid

AIRM1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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AIRM1 family

Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family

AIRM1 Subcellular locations

Membrane; Single-pass type I membrane protein.

AIRM1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

AIRM1 Sequence

DDBJ

EMBL

GenBank

AIRM1 3D structure

ModBase

AIRM1 interaction

STRING

AIRM1 Proteomic

PRIDE

AIRM1 Proteomic

Ensembl

GeneID

KEGG

UCSC

AIRM1 Organism specific

CTD

MGI

AIRM1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

AIRM1 Gene expression

Bgee

ArrayExpress

Genevestigator

AIRM1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY