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Human Proline-serine-threonine phosphatase-interacting 1 (aa 1-416)

CD2BP1 Swiss Prot#

O43586

CD2BP1 Protein names

Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)

CD2BP1 Gene names

PSTPIP1 (CD2BP1)

Organism

Human

CD2BP1 Entry name

PPIP1_HUMAN

CD2BP1 Codon optimized cDNA(gene) Clone

CD2BP1 Cat #

RPT0264

Tag

CD2BP1 contains A 6x histidine tag

CD2BP1 Formulation

Liquid

CD2BP1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CD2BP1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CD2BP1 Protein

CD2BP1 Cat #

PT0264

CD2BP1 Source

recombinant

CD2BP1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CD2BP1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CD2BP1 Activity

N/A

Tag

CD2BP1 Contains A 6x histidine tag

CD2BP1 Formulation

Liquid

CD2BP1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CD2BP1 family

-

CD2BP1 Subcellular locations

Cytoplasm. Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cytoplasm > perinuclear region. Cleavage furrow.

CD2BP1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2.

CD2BP1 Sequence

DDBJ

EMBL

GenBank

CD2BP1 3D structure

ModBase

CD2BP1 interaction

STRING

CD2BP1 Proteomic

PRIDE

CD2BP1 Proteomic

Ensembl

GeneID

KEGG

UCSC

CD2BP1 Organism specific

CTD

MGI

CD2BP1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CD2BP1 Gene expression

Bgee

ArrayExpress

Genevestigator

CD2BP1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY