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Human Inositol-tetrakisphosphate 1-kinase (aa 1-414)

ITPK1 Swiss Prot#

Q13572

ITPK1 Protein names

Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (Inositol-triphosphate 5/6-kinase) (EC 2.7.1.159) (Inositol 1,3,4-trisphosphate 5/6-kinase) (Ins(1,3,4)P(3) 5/6-kinase)

ITPK1 Gene names

ITPK1

Organism

Human

ITPK1 Entry name

ITPK1_HUMAN

ITPK1 Codon optimized cDNA(gene) Clone

ITPK1 Cat #

RPT0261

Tag

ITPK1 contains A 6x histidine tag

ITPK1 Formulation

Liquid

ITPK1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ITPK1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ITPK1 Protein

ITPK1 Cat #

PT0261

ITPK1 Source

recombinant

ITPK1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ITPK1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

ITPK1 Activity

N/A

Tag

ITPK1 Contains A 6x histidine tag

ITPK1 Formulation

Liquid

ITPK1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ITPK1 family

ITPK1 family

ITPK1 Subcellular locations

-

ITPK1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

ITPK1 Sequence

DDBJ

EMBL

GenBank

ITPK1 3D structure

ModBase

ITPK1 interaction

STRING

ITPK1 Proteomic

PRIDE

ITPK1 Proteomic

Ensembl

GeneID

KEGG

UCSC

ITPK1 Organism specific

CTD

MGI

ITPK1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ITPK1 Gene expression

Bgee

ArrayExpress

Genevestigator

ITPK1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY