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Human Myeloid cell surface antigen CD33 (aa 18-364)

SIGLEC3 Swiss Prot#

P20138

SIGLEC3 Protein names

Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33)

SIGLEC3 Gene names

CD33 (SIGLEC3)

Organism

Human

SIGLEC3 Entry name

CD33_HUMAN

SIGLEC3 Codon optimized cDNA(gene) Clone

SIGLEC3 Cat #

RPT0199

Tag

SIGLEC3 contains A 6x histidine tag

SIGLEC3 Formulation

Liquid

SIGLEC3 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

SIGLEC3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant SIGLEC3 Protein

SIGLEC3 Cat #

PT0199

SIGLEC3 Source

recombinant

SIGLEC3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

SIGLEC3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

SIGLEC3 Activity

N/A

Tag

SIGLEC3 Contains A 6x histidine tag

SIGLEC3 Formulation

Liquid

SIGLEC3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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SIGLEC3 family

Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family

SIGLEC3 Subcellular locations

Cell membrane; Single-pass type I membrane protein.

SIGLEC3 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).

SIGLEC3 Sequence

DDBJ

EMBL

GenBank

SIGLEC3 3D structure

ModBase

SIGLEC3 interaction

STRING

SIGLEC3 Proteomic

PRIDE

SIGLEC3 Proteomic

Ensembl

GeneID

KEGG

UCSC

SIGLEC3 Organism specific

CTD

MGI

SIGLEC3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SIGLEC3 Gene expression

Bgee

ArrayExpress

Genevestigator

SIGLEC3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY