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| Human Methylosome protein 50 (aa 1-342) |
| MEP50 Swiss Prot# | | Q9BQA1 |
| MEP50 Protein names | | Methylosome protein 50 (MEP-50) (WD repeat-containing protein 77) (Androgen receptor cofactor p44) (p44/Mep50) |
| MEP50 Gene names | | WDR77 (MEP50) (HKMT1069) (Nbla10071) |
| Organism | | Human |
| MEP50 Entry name | | MEP50_HUMAN |
| MEP50 Codon optimized cDNA(gene) Clone |
| MEP50 Cat # | | RPT0195 |
| Tag | | MEP50 contains A 6x histidine tag |
| MEP50 Formulation | | Liquid |
| MEP50 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| MEP50 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant MEP50 Protein |
| MEP50 Cat # | | PT0195 |
| MEP50 Source | | recombinant |
| MEP50 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| MEP50 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| MEP50 Activity | | N/A |
| Tag | | MEP50 Contains A 6x histidine tag |
| MEP50 Formulation | | Liquid |
| MEP50 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant MEP50 Products | | For pricing and availability Click Here >>> |
| MEP50 family | | - |
| MEP50 Subcellular locations | | Nucleus. Cytoplasm. |
| MEP50 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. |
| MEP50 Sequence | | DDBJ | EMBL | GenBank |
| MEP50 3D structure | | ModBase |
| MEP50 interaction | | STRING |
| MEP50 Proteomic | | PRIDE |
| MEP50 Proteomic | | Ensembl | GeneID | KEGG | UCSC |
| MEP50 Organism specific | | CTD | MGI |
| MEP50 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| MEP50 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| MEP50 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |