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Human Methylosome protein 50 (aa 1-342)
MEP50 Swiss Prot#
Q9BQA1
MEP50 Protein names
Methylosome protein 50 (MEP-50) (WD repeat-containing protein 77) (Androgen receptor cofactor p44) (p44/Mep50)
MEP50 Gene names
WDR77 (MEP50) (HKMT1069) (Nbla10071)
Organism
Human
MEP50 Entry name
MEP50_HUMAN
MEP50 Codon optimized cDNA(gene) Clone
MEP50 Cat #
RPT0195
Tag
MEP50 contains A 6x histidine tag
MEP50 Formulation
Liquid
MEP50 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
MEP50 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant MEP50 Protein
MEP50 Cat #
PT0195
MEP50 Source
recombinant
MEP50 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
MEP50 Purity
>90%, as determined by SDS-PAGE under reducing conditions
MEP50 Activity
N/A
Tag
MEP50 Contains A 6x histidine tag
MEP50 Formulation
Liquid
MEP50 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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MEP50 family
-
MEP50 Subcellular locations
Nucleus. Cytoplasm.
MEP50 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
MEP50 Sequence
DDBJ EMBL GenBank
MEP50 3D structure
ModBase
MEP50 interaction
STRING
MEP50 Proteomic
PRIDE
MEP50 Proteomic
Ensembl GeneID KEGG UCSC
MEP50 Organism specific
CTD MGI
MEP50 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
MEP50 Gene expression
Bgee ArrayExpress Genevestigator
MEP50 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY