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Human Laforin (aa 1-331)

EPM2A Swiss Prot#

O95278

EPM2A Protein names

Laforin (EC 3.1.3.48) (EC 3.1.3.16) (Lafora PTPase) (LAFPTPase)

EPM2A Gene names

EPM2A

Organism

Human

EPM2A Entry name

EPM2A_HUMAN

EPM2A Codon optimized cDNA(gene) Clone

EPM2A Cat #

RPT0185

Tag

EPM2A contains A 6x histidine tag

EPM2A Formulation

Liquid

EPM2A Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

EPM2A Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant EPM2A Protein

EPM2A Cat #

PT0185

EPM2A Source

recombinant

EPM2A Applications

Western Blot, SDS-Page or may be used for other applications determined by user

EPM2A Purity

>90%, as determined by SDS-PAGE under reducing conditions

EPM2A Activity

N/A

Tag

EPM2A Contains A 6x histidine tag

EPM2A Formulation

Liquid

EPM2A Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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EPM2A family

Protein-tyrosine phosphatase family

EPM2A Subcellular locations

Cytoplasm. Endoplasmic reticulum. Cell membrane. Endoplasmic reticulum. Cell membrane. Nucleus.

EPM2A FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Dual specificity protein phosphatase. May be involved in the control of glycogen metabolism, particularly in monitoring for and preventing the formation of poorly branched glycogen molecules (polyglucosans). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Forms a complex with NHLRC1/malin and HSP70 and this complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS).

EPM2A Sequence

DDBJ

EMBL

GenBank

EPM2A 3D structure

ModBase

EPM2A interaction

STRING

EPM2A Proteomic

PRIDE

EPM2A Proteomic

Ensembl

GeneID

KEGG

UCSC

EPM2A Organism specific

CTD

MGI

EPM2A Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

EPM2A Gene expression

Bgee

ArrayExpress

Genevestigator

EPM2A Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY