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Human Serine threonine-protein phosphatase 2A alpha (aa 1-309)

PPP2CA Swiss Prot#

P67775

PPP2CA Protein names

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)

PPP2CA Gene names

PPP2CA

Organism

Human

PPP2CA Entry name

PP2AA_HUMAN

PPP2CA Codon optimized cDNA(gene) Clone

PPP2CA Cat #

RPT0164

Tag

PPP2CA contains A 6x histidine tag

PPP2CA Formulation

Liquid

PPP2CA Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PPP2CA Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PPP2CA Protein

PPP2CA Cat #

PT0164

PPP2CA Source

recombinant

PPP2CA Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PPP2CA Purity

>90%, as determined by SDS-PAGE under reducing conditions

PPP2CA Activity

N/A

Tag

PPP2CA Contains A 6x histidine tag

PPP2CA Formulation

Liquid

PPP2CA Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PPP2CA family

PPP phosphatase family, PP-1 subfamily

PPP2CA Subcellular locations

Cytoplasm. Nucleus. Chromosome > centromere. Cytoplasm > cytoskeleton > spindle pole.

PPP2CA FUNCTION According to UniProtKB Swiss Prot

FUNCTION: PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen.

PPP2CA Sequence

DDBJ

EMBL

GenBank

PPP2CA 3D structure

ModBase

PPP2CA interaction

STRING

PPP2CA Proteomic

PRIDE

PPP2CA Proteomic

Ensembl

GeneID

KEGG

UCSC

PPP2CA Organism specific

CTD

MGI

PPP2CA Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PPP2CA Gene expression

Bgee

ArrayExpress

Genevestigator

PPP2CA Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY