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Human Leukocyte-associated immunoglobulin-like 1 (aa 22-287)

CD305 Swiss Prot#

Q6GTX8

CD305 Protein names

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305)

CD305 Gene names

LAIR1 (CD305)

Organism

Human

CD305 Entry name

LAIR1_HUMAN

CD305 Codon optimized cDNA(gene) Clone

CD305 Cat #

RPT0130

Tag

CD305 contains A 6x histidine tag

CD305 Formulation

Liquid

CD305 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CD305 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CD305 Protein

CD305 Cat #

PT0130

CD305 Source

recombinant

CD305 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CD305 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CD305 Activity

N/A

Tag

CD305 Contains A 6x histidine tag

CD305 Formulation

Liquid

CD305 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CD305 family

-

CD305 Subcellular locations

Cell membrane; Single-pass type I membrane protein.

CD305 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, downregulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

CD305 Sequence

DDBJ

EMBL

GenBank

CD305 3D structure

ModBase

CD305 interaction

STRING

CD305 Proteomic

PRIDE

CD305 Proteomic

Ensembl

GeneID

KEGG

UCSC

CD305 Organism specific

CTD

MGI

CD305 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CD305 Gene expression

Bgee

ArrayExpress

Genevestigator

CD305 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY