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Human Phospholipase D6 (aa 1-252)

PLD6 Swiss Prot#

Q8N2A8

PLD6 Protein names

Phospholipase D6 (PLD 6) (EC 3.1.4.4) (Choline phosphatase 6) (Phosphatidylcholine-hydrolyzing phospholipase D6)

PLD6 Gene names

PLD6

Organism

Human

PLD6 Entry name

PLD6_HUMAN

PLD6 Codon optimized cDNA(gene) Clone

PLD6 Cat #

RPT0118

Tag

PLD6 contains A 6x histidine tag

PLD6 Formulation

Liquid

PLD6 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PLD6 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PLD6 Protein

PLD6 Cat #

PT0118

PLD6 Source

recombinant

PLD6 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PLD6 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PLD6 Activity

N/A

Tag

PLD6 Contains A 6x histidine tag

PLD6 Formulation

Liquid

PLD6 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PLD6 family

Phospholipase D family, MitoPLD/Zucchini subfamily

PLD6 Subcellular locations

Mitochondrion outer membrane; Single-pass membrane protein.

PLD6 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. Required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.

PLD6 Sequence

DDBJ

EMBL

GenBank

PLD6 3D structure

ModBase

PLD6 interaction

STRING

PLD6 Proteomic

PRIDE

PLD6 Proteomic

Ensembl

GeneID

KEGG

UCSC

PLD6 Organism specific

CTD

MGI

PLD6 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PLD6 Gene expression

Bgee

ArrayExpress

Genevestigator

PLD6 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY