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Human Histone H2A.x (aa 1-143)

H2AX Swiss Prot#

P16104

H2AX Protein names

Histone H2A.x (H2a/x)

H2AX Gene names

H2AFX (H2AX)

Organism

Human

H2AX Entry name

H2AX_HUMAN

H2AX Codon optimized cDNA(gene) Clone

H2AX Cat #

RPT0007

Tag

H2AX contains A 6x histidine tag

H2AX Formulation

Liquid

H2AX Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

H2AX Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant H2AX Protein

H2AX Cat #

PT0007

H2AX Source

recombinant

H2AX Applications

Western Blot, SDS-Page or may be used for other applications determined by user

H2AX Purity

>90%, as determined by SDS-PAGE under reducing conditions

H2AX Activity

N/A

Tag

H2AX Contains A 6x histidine tag

H2AX Formulation

Liquid

H2AX Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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H2AX family

Histone H2A family

H2AX Subcellular locations

Nucleus. Chromosome.

H2AX FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

H2AX Sequence

DDBJ

EMBL

GenBank

H2AX 3D structure

ModBase

H2AX interaction

STRING

H2AX Proteomic

PRIDE

H2AX Proteomic

Ensembl

GeneID

KEGG

UCSC

H2AX Organism specific

CTD

MGI

H2AX Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

H2AX Gene expression

Bgee

ArrayExpress

Genevestigator

H2AX Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY