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Rat G protein-activated inward rectifier potassium 1 (aa 1-501)

Girk1 Swiss Prot#

P63251

Girk1 Protein names

G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Potassium channel, inwardly rectifying subfamily J member 3) (Inward rectifier K(+) channel Kir3.1) (KGA) (KGB1)

Girk1 Gene names

Kcnj3 Girk1 Kga

Organism

Rat

Girk1 Entry name

IRK3_RAT

Girk1 Codon optimized cDNA(gene) Clone

Girk1 Cat #

RPX3187

Tag

Girk1 contains A 6x histidine tag

Girk1 Formulation

Liquid

Girk1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Girk1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Girk1 Protein

Girk1 Cat #

PX3187

Girk1 Source

recombinant

Girk1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Girk1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Girk1 Activity

N/A

Tag

Girk1 Contains A 6x histidine tag

Girk1 Formulation

Liquid

Girk1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Girk1 family

Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ3 subfamily

Girk1 Subcellular locations

Membrane; Multi-pass membrane protein.

Girk1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

Girk1 Sequence

DDBJ

EMBL

GenBank

Girk1 3D structure

ModBase

Girk1 interaction

STRING

Girk1 Proteomic

PRIDE

Girk1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Girk1 Organism specific

CTD

MGI

Girk1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Girk1 Gene expression

Bgee

ArrayExpress

Genevestigator

Girk1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY