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| Rat Beta-arrestin-2 (aa 1-410) |
| Arrb2 Swiss Prot# | | P29067 |
| Arrb2 Protein names | | Beta-arrestin-2 (Arrestin beta-2) |
| Arrb2 Gene names | | Arrb2 |
| Organism | | Rat |
| Arrb2 Entry name | | ARRB2_RAT |
| Arrb2 Codon optimized cDNA(gene) Clone |
| Arrb2 Cat # | | RPX3143 |
| Tag | | Arrb2 contains A 6x histidine tag |
| Arrb2 Formulation | | Liquid |
| Arrb2 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Arrb2 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Arrb2 Protein |
| Arrb2 Cat # | | PX3143 |
| Arrb2 Source | | recombinant |
| Arrb2 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| Arrb2 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Arrb2 Activity | | N/A |
| Tag | | Arrb2 Contains A 6x histidine tag |
| Arrb2 Formulation | | Liquid |
| Arrb2 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant Arrb2 Products | | For pricing and availability Click Here >>> |
| Arrb2 family | | Arrestin family |
| Arrb2 Subcellular locations | | Cytoplasm. Nucleus. Cell membrane. Membrane > clathrin-coated pit. Cytoplasmic vesicle. |
| Arrb2 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. |
| Arrb2 Sequence | | DDBJ | EMBL | GenBank |
| Arrb2 3D structure | | ModBase |
| Arrb2 interaction | | STRING |
| Arrb2 Proteomic | | PRIDE |
| Arrb2 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| Arrb2 Organism specific | | CTD | MGI |
| Arrb2 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| Arrb2 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| Arrb2 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
