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Rat Beta-arrestin-1 (aa 1-418)

Arrb1 Swiss Prot#

P29066

Arrb1 Protein names

Beta-arrestin-1 (Arrestin beta-1)

Arrb1 Gene names

Arrb1

Organism

Rat

Arrb1 Entry name

ARRB1_RAT

Arrb1 Codon optimized cDNA(gene) Clone

Arrb1 Cat #

RPX3142

Tag

Arrb1 contains A 6x histidine tag

Arrb1 Formulation

Liquid

Arrb1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Arrb1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Arrb1 Protein

Arrb1 Cat #

PX3142

Arrb1 Source

recombinant

Arrb1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Arrb1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Arrb1 Activity

N/A

Tag

Arrb1 Contains A 6x histidine tag

Arrb1 Formulation

Liquid

Arrb1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Arrb1 family

Arrestin family

Arrb1 Subcellular locations

Cytoplasm. Nucleus. Cell membrane. Membrane > clathrin-coated pit. Cell projection > pseudopodium. Cytoplasmic vesicle.

Arrb1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling.

Arrb1 Sequence

DDBJ

EMBL

GenBank

Arrb1 3D structure

ModBase

Arrb1 interaction

STRING

Arrb1 Proteomic

PRIDE

Arrb1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Arrb1 Organism specific

CTD

MGI

Arrb1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Arrb1 Gene expression

Bgee

ArrayExpress

Genevestigator

Arrb1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY