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Rat G-protein coupled receptor 109A (aa 1-360)

Gpr109 Swiss Prot#

Q80Z39

Gpr109 Protein names

G-protein coupled receptor 109A (Niacin receptor 1) (Nicotinic acid receptor) (G-protein coupled receptor 109) (G-protein coupled receptor HM74) (Protein PUMA-G)

Gpr109 Gene names

Gpr109a Gpr109 Gpr109b Niacr1 Pumag

Organism

Rat

Gpr109 Entry name

G109A_RAT

Gpr109 Codon optimized cDNA(gene) Clone

Gpr109 Cat #

RPX3007

Tag

Gpr109 contains A 6x histidine tag

Gpr109 Formulation

Liquid

Gpr109 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Gpr109 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Gpr109 Protein

Gpr109 Cat #

PX3007

Gpr109 Source

recombinant

Gpr109 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Gpr109 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Gpr109 Activity

N/A

Tag

Gpr109 Contains A 6x histidine tag

Gpr109 Formulation

Liquid

Gpr109 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Gpr109 family

G-protein coupled receptor 1 family

Gpr109 Subcellular locations

Cell membrane; Multi-pass membrane protein.

Gpr109 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.

Gpr109 Sequence

DDBJ

EMBL

GenBank

Gpr109 3D structure

ModBase

Gpr109 interaction

STRING

Gpr109 Proteomic

PRIDE

Gpr109 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Gpr109 Organism specific

CTD

MGI

Gpr109 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Gpr109 Gene expression

Bgee

ArrayExpress

Genevestigator

Gpr109 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY