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Mouse Cytokine-inducible SH2-containing protein (aa 17-257)

Cis Swiss Prot#

Q62225

Cis Protein names

Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS)

Cis Gene names

Cish Cis

Organism

Mouse

Cis Entry name

CISH_MOUSE

Cis Codon optimized cDNA(gene) Clone

Cis Cat #

RPX1535

Tag

Cis contains A 6x histidine tag

Cis Formulation

Liquid

Cis Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Cis Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Cis Protein

Cis Cat #

PX1535

Cis Source

recombinant

Cis Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Cis Purity

>90%, as determined by SDS-PAGE under reducing conditions

Cis Activity

N/A

Tag

Cis Contains A 6x histidine tag

Cis Formulation

Liquid

Cis Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Cis family

-

Cis Subcellular locations

-

Cis FUNCTION According to UniProtKB Swiss Prot

FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Cis Sequence

DDBJ

EMBL

GenBank

Cis 3D structure

ModBase

Cis interaction

STRING

Cis Proteomic

PRIDE

Cis Genome annotation

Ensembl

GeneID

KEGG

UCSC

Cis Organism specific

CTD

MGI

Cis Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Cis Gene expression

Bgee

ArrayExpress

Genevestigator

Cis Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY