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| Mouse Angiotensinogen (aa 24-477) |
| Serpina8 Swiss Prot# | | P11859 |
| Serpina8 Protein names | | Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II)] |
| Serpina8 Gene names | | Agt Serpina8 |
| Organism | | Mouse |
| Serpina8 Entry name | | ANGT_MOUSE |
| Serpina8 Codon optimized cDNA(gene) Clone |
| Serpina8 Cat # | | RPX1460 |
| Tag | | Serpina8 contains A 6x histidine tag |
| Serpina8 Formulation | | Liquid |
| Serpina8 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Serpina8 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Serpina8 Protein |
| Serpina8 Cat # | | PX1460 |
| Serpina8 Source | | recombinant |
| Serpina8 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| Serpina8 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Serpina8 Activity | | N/A |
| Tag | | Serpina8 Contains A 6x histidine tag |
| Serpina8 Formulation | | Liquid |
| Serpina8 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant Serpina8 Products | | For pricing and availability Click Here >>> |
| Serpina8 family | | Serpin family |
| Serpina8 Subcellular locations | | Secreted. |
| Serpina8 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8) (By similarity). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin) (By similarity). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 (By similarity).; FUNCTION: Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (By similarity).; FUNCTION: Angiotensin-3 stimulates aldosterone release (By similarity).; FUNCTION: Angiotensin 1-7 is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets. |
| Serpina8 Sequence | | DDBJ | EMBL | GenBank |
| Serpina8 3D structure | | ModBase |
| Serpina8 interaction | | STRING |
| Serpina8 Proteomic | | PRIDE |
| Serpina8 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| Serpina8 Organism specific | | CTD | MGI |
| Serpina8 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| Serpina8 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| Serpina8 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |