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Mouse Angiotensinogen (aa 24-477)
Serpina8 Swiss Prot#
P11859
Serpina8 Protein names
Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II)]
Serpina8 Gene names
Agt Serpina8
Organism
Mouse
Serpina8 Entry name
ANGT_MOUSE
Serpina8 Codon optimized cDNA(gene) Clone
Serpina8 Cat #
RPX1460
Tag
Serpina8 contains A 6x histidine tag
Serpina8 Formulation
Liquid
Serpina8 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Serpina8 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Serpina8 Protein
Serpina8 Cat #
PX1460
Serpina8 Source
recombinant
Serpina8 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
Serpina8 Purity
>90%, as determined by SDS-PAGE under reducing conditions
Serpina8 Activity
N/A
Tag
Serpina8 Contains A 6x histidine tag
Serpina8 Formulation
Liquid
Serpina8 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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Serpina8 family
Serpin family
Serpina8 Subcellular locations
Secreted.
Serpina8 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8) (By similarity). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin) (By similarity). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 (By similarity).; FUNCTION: Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (By similarity).; FUNCTION: Angiotensin-3 stimulates aldosterone release (By similarity).; FUNCTION: Angiotensin 1-7 is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
Serpina8 Sequence
DDBJ EMBL GenBank
Serpina8 3D structure
ModBase
Serpina8 interaction
STRING
Serpina8 Proteomic
PRIDE
Serpina8 Genome annotation
Ensembl GeneID KEGG UCSC
Serpina8 Organism specific
CTD MGI
Serpina8 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Serpina8 Gene expression
Bgee ArrayExpress Genevestigator
Serpina8 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY