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Mouse Metastasis-suppressor KiSS-1 (aa 24-130)

Kiss1 Swiss Prot#

Q6Y4S4

Kiss1 Protein names

Metastasis-suppressor KiSS-1 (Kisspeptin-1) [Cleaved into: Metastin (Kisspeptin-52); Kisspeptin-10 (Metastin45-54)]

Kiss1 Gene names

Kiss1

Organism

Mouse

Kiss1 Entry name

KISS1_MOUSE

Kiss1 Codon optimized cDNA(gene) Clone

Kiss1 Cat #

RPX1457

Tag

Kiss1 contains A 6x histidine tag

Kiss1 Formulation

Liquid

Kiss1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Kiss1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Kiss1 Protein

Kiss1 Cat #

PX1457

Kiss1 Source

recombinant

Kiss1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Kiss1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Kiss1 Activity

N/A

Tag

Kiss1 Contains A 6x histidine tag

Kiss1 Formulation

Liquid

Kiss1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Kiss1 family

KISS1 family

Kiss1 Subcellular locations

Secreted.

Kiss1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Intracerebroventricular administration induces an increase in serum LH and FSH levels in prepubertal male and female as well as in adult animals.

Kiss1 Sequence

DDBJ

EMBL

GenBank

Kiss1 3D structure

ModBase

Kiss1 interaction

STRING

Kiss1 Proteomic

PRIDE

Kiss1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Kiss1 Organism specific

CTD

MGI

Kiss1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Kiss1 Gene expression

Bgee

ArrayExpress

Genevestigator

Kiss1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY